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2026 Compound

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Cancer Vaccines
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Cancer Vaccines

Vaccinate yourself against your own tumor

Short Description

Vaccinate yourself against your own tumor to train your body to proactively protect against recurrence

Long Description

The cancer vaccine field has yet to become a systematic science despite decades of work and a steadily rising number of clinical trials since the first clinical PoC a decade ago.

In its Phase II readout, Moderna’s mRNA-4157 therapy in combination with Keytruda significantly improved outcomes for patients with resected stage III/IV melanoma. However, even that study has major caveats.

The Field’s Stumbling Blocks

  • Lack of Modality and Parameter Benchmarking
  • Abjectly Bad Prediction Algorithms
  • Basic Biology and Prediction of Presentation
  • Proper Biological Validation
  • Tumor Heterogeneity

We at Compound are excited about more comprehensive assays (full genome sequencing, more relevant readout, etc), novel target spaces & manufacturing leaps

Comparable Companies

https://www.modernatx.com/en-US

https://www.biontech.com/int/en/home.html

Infinitopes https://www.infinitopes.com/

https://evaxion.ai/

https://immunomix.com/

https://www.curevac.com/en/

https://nouscom.com/

https://popvax.com/

Further Reading

https://www.mackenziemorehead.com/the-failures-and-futures-of-cancer-vaccines/

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